Eugenol [2-methoxy-4-(2-propenyl)phenol] prevents 6-hydroxydopamine-induced dopamine depression and lipid peroxidation inductivity in mouse striatum.
Kagawa Prefectural College of Health Sciences - Kagawa, Japan. Published March 2007.
- Dopamine is a chemical used by the body so that nerve cells can communicate with each other.
- Parkinson's Disease is characterized by progressive degeneration of neurons that use dopamine as well as lowered levels of dopamine in the brain.
- Damage of these dopamine-using neurons by oxygen derived free radicals is considered to be an important contributing mechanism to Parkinson's Disease.
- 6-OHDA is used to produce an animal model of Parkinson's Disease. 6-OHDA is toxic because it produces free radicals and a buildup of hydrogen peroxide and superoxide.
- Organisms have developed natural enzyme systems to protect from damage from these free radicals.
- Eugenol is an essential oil constituent of Clove.
- Control groups used a saline solution, whereas the other groups were given varying doses of Eugenol.
- Mice were given a daily dose of Eugenol for 3 days. Afterwards 6-OHDA, which induces Parkinson's Disease, was injected into their brain. After inducing Parkinson's, the mice were given daily doses of Eugenol for the next 7 days.
- Eugenol helped reduce the loss of Dopamine, DOPAC, and HVA that was caused by Parkinson's Disease (6-OHDA). See charts below.
- Eugenol protected the dopamine-using neurons in the brain by helping to stop the oxidation of lipids in the cell membranes which produce more free radicals. This in turn allows enzymes (Catalase & GPx) that break down free radicals and convert Hydrogen Peroxide back into Water to be more effective.