There's been a lot of talk about the idea of doing a practical career vs doing one you're passionate about. Beyond the point that the kind of career considered "practical" in our parent's day doesn't really exist any more, I think that perhaps I can rephrase this as something that draws a more important distinction.
I think that the practical vs passionate choice is a false one. All that practical means, or should mean, is that you can make a living off of it-if you want to get all ethical, you could add "without hurting other people" to that. Unfortunately, quite a lot of people cram a lot of other considerations in there when deciding what does or should count as a practical/respectable/whatever, and most of those don't have anything to do with how useful the job is to apes, or how beneficial it is to the ape/meme-creature performing the job, they're all about the meme-creatures causing the apes to criticize it.
It is a definite fact that people perform jobs they're passionate about better than ones they aren't. If they're sufficiently apathetic about it, they might even produce negative value at it-see the characters in Dilbert. But a passionate person will make a huge difference at whatever they're doing. The problem is that apes don't tend to be passionate about the things the meme-creatures running society want them to be. While meme-creatures can stir up passions, they also often cannot. Our animal passions rule us as often as not.
Here's an example of something that apes are big into but a lot of meme-creatures are opposed to: consensual, harmless, frequent, frivolous sex. Man apes love having sex. Meme-creatures often try to exploit this, but seem to have a strange tendency to oppose it. Maybe it's because they don't reproduce sexually? Anyways, this results in a lot of societal pressures against people making money in ways that directly involve sex. This means that there is a huge, barely tapped market there!
My partner is a sex worker. Now it's fortunate that the horrid meme-creature known as Monogamy never got its hooks into either of us, which means that its terrible weapon Jealousy the Envy-Blade, Breaker of Relationships, passes through me like the aethereal nothingness that it is, leaving me wrapped in the warm glow of my Breastplate of Compersion, That Which Heals When Hurt. This means we're open to explore those means of making money. Both of us have worked in pornography, making decent wages. But she's now working directly as an escort, which, given that she is an incredibly sexy, intelligent, and particularly business savvy lady, is making her quite a bit more. She tells me it is uncouth to discuss money explicitly, but I will say that this is earning much more money working far fewer hours than any of the "legitimate" jobs that either of us have worked.
Where am I going will all this? Well, basically, figure out the intersection of what you're passionate about and what people pay money for. For me, it's boardgames. For my partner, it's sex. Then figure out how to do that and capture some of that money. For some people this will involve working for somebody else at an established company, but I bet that that is true of far fewer people than currently do it. So if the signs are pointing you in the direction of starting your own business, follow those signs, and do it!
The main lesson I want to impart is that meme-creatures will tell you not to do things that are in your own best interest! They don't tell you this explicitly most of the time, because that's not how anyone talks, especially meme-creatures, but instead they'll do things like make you feel vaguely uneasy or disgusted at an idea, or reflexively consider it immoral, or look down on people who do it. So to that I say that you need simply remember the true meaning of morality: making the world a better place, by whatever standard you judge best. It is not in following arbitrary rules. It is in the consequences of your actions.